Papers for cardiomyocyte maturation
Sakamoto…Kelly; 2023; JMCC
Maturing differentiated human pluripotent stem cells in vitro: methods and challenges
(Ottaviani…Mummery; 2023; Development)
- TNNI1/TNNI3 (Bedada et al 2014)
- MYL4/MYL3 (different review from Guo, 2018)
- MYL7/MYL2 (FInck 2007)
- MYH6/MYH7 (CUi et al 2019)
- SCNA5A Nav1.5e(exon 6A)/Nav1.5(exon 6B) (Onkal et al. 2008)
- CACNB2 CaVbeta2a-N1/ CaVbeta2a-N4 CaVbeta2a-N5 (LInk et al 2009)
- Titin N2BA/N2BB (Opitz et al 2004)
- Tropomyosin TPM1kappa/TPM1alpha (Weeland 2015)
- Cytochrome c oxidase subunit 8 (COX8) COX8A/COX8B (Calmettes et al 2013)
- PGC1alpha (reviewd in Sakamoto et al refs 23,56)
Hierarchical and stage-specific regulation of murine cardiomyocyte maturation by serum response factor
(Yuxuan Guo…Pu WT; 2018; Nat Commun) Nice review
Review on 3D models from Mummery lab
(Campostrini…Mummery; 2021, Circulation Research)
Review on changes in several aspects of physiology accross species
(Dimasi…Morrison; J Physiol.-London; 2023)
PGC1/PPAR regulate CM maturation through YAP1
(Murphy…Kwon; 2021;Nature Communications)
Show that agonists for PGC1 make maturaiton and hypertrophy, conditional KO of YAP1 is smaller, when you inhibit YAP1 overrides the phenotype. They are using some strange YAP1 inhibitor (R)-PFI-2 which works through SETD7 mehtyltransferase (Barytse-Lovejoy…Arrowsmith; 2014; PNAS)